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1

A clinicopathological study of gastric cancer with special reference to age of the patients: An analysis of 1,630 cases

Tetsuya Mitsudomi, Toshimitsu Matsusaka, Kenzo Wakasugi, Masaharu Takenaka, Kazuhiro Kume, Yutaka Fujinaga, Hiroaki Teraoka, Akinori Iwashita

Journal:

World Journal of Surgery

Année:

1989

Langue:

english

Fichier:

PDF, 654 KB

english, 1989

2

Total Synthesis and Comparative Evaluation of Luzopeptin A−C and Quinoxapeptin A−C

Boger, Dale L., Ledeboer, Mark W., Kume, Masaharu, Searcey, Mark, Jin, Qing

Journal:

Journal of the American Chemical Society

Année:

1999

Langue:

english

Fichier:

PDF, 268 KB

english, 1999

3

Totalsynthese von Chinoxapeptin A–C: Bestimmung der absoluten Konfiguration

Dale L. Boger, Mark W. Ledeboer, Masaharu Kume, Qing Jin

Journal:

Angewandte Chemie

Année:

1999

Langue:

german

Fichier:

PDF, 110 KB

german, 1999

4

Total Synthesis of Quinoxapeptin A–C: Establishment of Absolute Stereochemistry

Dale L. Boger, Mark W. Ledeboer, Masaharu Kume, Qing Jin

Journal:

Angewandte Chemie International Edition

Année:

1999

Langue:

english

Fichier:

PDF, 111 KB

english, 1999

5

ChemInform Abstract: Total Synthesis and Comparative Evaluation of Luzopeptin A—C and Quinoxapeptin A—C.

Dale L. Boger, Mark W. Ledeboer, Masaharu Kume, Mark Searcey, Qing Jin

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 32 KB

english, 2000

6

Novel Antibacterial Macrolides: Synthesis of 15-Membered Diolides.

Takafumi Ohara, Masaharu Kume, Yukitoshi Narukawa, Kiyoshi Motokawa, Kouichi Uotani, Hiroshi Nakai

Journal:

Année:

2003

Fichier:

PDF, 112 KB

2003

7

Novel and efficient synthesis of 1β-methylcarbapenems utilizing cyclization of hypervalent iodonium ylides

Masaharu Kume, Tadatoshi Kubota, Yasuyoshi Iso

Journal:

Tetrahedron Letters

Année:

1995

Langue:

english

Fichier:

PDF, 199 KB

english, 1995

8

Efficient and practical synthesis of 1⊝methylcarbapenems

Masaharu Kume, Hiroaki Ooka, Hiroyuki Ishitobi

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 794 KB

english, 1997

9

Serofendic Acid, a Substance Extracted from Fetal Calf Serum, as a Novel Drug for Cardioprotection

Masaharu Akao, Toshihiro Takeda, Toru Kita, Toshiaki Kume, Akinori Akaike

Journal:

Cardiovascular Therapeutics

Année:

2007

Langue:

english

Fichier:

PDF, 158 KB

english, 2007

10

ChemInform Abstract: Total Synthesis of Luzopeptins A—C.

Dale L. Boger, Mark W. Ledeboer, Masaharu Kume

Journal:

Année:

1999

Fichier:

PDF, 25 KB

1999

11

Serofendic acid, a neuroprotective substance derived from fetal calf serum, inhibits mitochondrial membrane depolarization and caspase-3 activation

Toshiaki Kume, Ryota Taguchi, Hiroshi Katsuki, Masaharu Akao, Hachiro Sugimoto, Shuji Kaneko, Akinori Akaike

Journal:

European Journal of Pharmacology

Année:

2006

Langue:

english

Fichier:

PDF, 450 KB

english, 2006

12

Diet modification and its influence on metabolic and related pathological alterations in the SHR/NDmcr-cp rat, an animal model of the metabolic syndrome

Kouji Kawai, Tetsuya Sakairi, Shuichi Harada, Junko Shinozuka, Mika Ide, Hiroko Sato, Masaharu Tanaka, Wataru Toriumi, Eisuke Kume

Journal:

Experimental and Toxicologic Pathology

Année:

2012

Langue:

english

Fichier:

PDF, 1.23 MB

english, 2012

13

Power spectral analysis of heart rate variability in type a females during a psychomotor task

Nozomi Sato, Toyohiko Kamada, Shinji Miyake, Jun’Ichi Akatsu, Masaharu Kumashiro, Yasufumi Kume

Journal:

Journal of Psychosomatic Research

Année:

1998

Langue:

english

Fichier:

PDF, 159 KB

english, 1998

14

Serofendic Acid, a Novel Substance Extracted From Fetal Calf Serum, Protects Against Oxidative Stress in Neonatal Rat Cardiac Myocytes

Toshihiro Takeda, Masaharu Akao, Madoka Matsumoto-Ida, Masashi Kato, Hiroyuki Takenaka, Yasuki Kihara, Toshiaki Kume, Akinori Akaike, Toru Kita

Journal:

Journal of the American College of Cardiology

Année:

2006

Langue:

english

Fichier:

PDF, 682 KB

english, 2006

15

Total Synthesis of Luzopeptins A−C

Boger, Dale L., Ledeboer, Mark W., Kume, Masaharu

Journal:

Journal of the American Chemical Society

Année:

1999

Langue:

english

Fichier:

PDF, 95 KB

english, 1999

16

Novel Antibacterial Macrolides: Synthesis of 15-Membered Diolides

Ohara, Takafumi, Kume, Masaharu, Narukawa, Yukitoshi, Motokawa, Kiyoshi, Uotani, Kouichi, Nakai, Hiroshi

Journal:

Journal of Organic Chemistry

Année:

2002

Langue:

english

Fichier:

PDF, 249 KB

english, 2002

17

Chiral synthesis of a useful intermediate for (+)-isocarbacyclin

Nagao, Yoshimitsu, Nakiamura, Takeshi, Kume, Masaharu, Ochiai, Masahito, Fuji, Kaoru, Fujita, Eiichi

Journal:

Journal of the Chemical Society Chemical Communications

Année:

1987

Langue:

english

Fichier:

PDF, 174 KB

english, 1987

18

344. AAV Vector-Mediated Msx1 Gene Transfer Induces Hematopoietic Stem/Progenitor Cells in Skeletal Muscle

Nobuyoshi, Masaharu, Kume, Akihiro, Matsushita, Takashi, Mizukami, Hiroaki, Okada, Takashi, Urabe, Masashi, Ohgoshi, Yuichi, Endo, Takashi, Ozawa, Keiya

Journal:

Molecular Therapy

Année:

2006

Langue:

english

Fichier:

PDF, 84 KB

english, 2006

19

Efficient Preparation of New Chiral Synthons Useful for (+)-Carbacyclin Synthsis by Utilizing Enzymatic Hydrolysis of Prochiral σ-Symmetric Diesters

Nagao, Yoshimitsu, Kume, Masaharu, Wakabayashi, Robin Chikako, Nakamura, Takeshi, Ochiai, Masahito

Journal:

Chemistry Letters

Année:

1989

Fichier:

PDF, 333 KB

1989

20

Enzymatic Hydrolyses of the σ-Symmetric Dicarboxylic Diesters Bearing a Sulfinyl Group as the Prochiral Center

Tamai, Satoshi, Miyauchi, Satoru, Morizane, Chikako, Miyagi, Kaname, Shimizu, Hisashi, Kume, Masaharu, Sano, Sigeki, Shiro, Motoo, Nagao, Yoshimitsu

Journal:

Chemistry Letters

Année:

1994

Fichier:

PDF, 359 KB

1994

21

Remarkable Effect of D-Sorbitol on the Second Stage in the PLE-Catalyzed Hydrolyses of a σ-Symmetric Diester, cis -Cyclohex-4-ene-1,2-bis(methyl acetate)

Nagao, Yoshimitsu, Tohjo, Toshiaki, Kaneuchi, Tohru, Yukimoto, Yusuke, Kume, Masaharu

Journal:

Chemistry Letters

Année:

1992

Fichier:

PDF, 329 KB

1992

22

Orally Active Cephalosporins. IV. Synthesis, Antibacterial Activity and Oral Absorption of 3-(1H-1,2,3-Triazol-4-yl)thiomethylthio-cephalosporins.

KUME, Masaharu, KUBOTA, Tadatoshi, KIMURA, Yasuo, NAKASHIMIZU, Hiromu, MOTOKAWA, Kiyoshi

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Année:

1993

Fichier:

PDF, 731 KB

1993

23

Orally active cephalosporins. II. Synthesis and structure-activity relationships of new 7.BETA.-((Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-cephalosporins with 1,2,3-triazole in C-3 side chain.

KUME, MASAHARU, KUBOTA, TADATOSHI, KIMURA, YASUO, NAKASHIMIZU, HIROMU, MOTOKAWA, KIYOSHI, NAKANO, MASAO

Journal:

The Journal of Antibiotics

Année:

1993

Langue:

english

Fichier:

PDF, 893 KB

english, 1993

24

Orally active cephalosporins. III. Synthesis and structure-activity relationships of new 3-heterocyclicthiomethylthio-7.BETA.-((Z)-2(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-cephem-4-carboxylic acids.

KUME, MASAHARU, KUBOTA, TADATOSHI, KIMURA, YASUO, NAKASHIMIZU, HIROMU, MOTOKAWA, KIYOSHI

Journal:

The Journal of Antibiotics

Année:

1993

Langue:

english

Fichier:

PDF, 842 KB

english, 1993

25

Serofendic Acid Protects Against Myocardial Ischemia–Reperfusion Injury in Rats

Ioroi, Tadaaki, Akao, Masaharu, Iguchi, Moritake, Kato, Masashi, Kimura, Takeshi, Izumi, Yasuhiko, Akaike, Akinori, Kume, Toshiaki

Journal:

Journal of Pharmacological Sciences

Année:

2014

Langue:

english

Fichier:

PDF, 1.99 MB

english, 2014

26

Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 1: Initial structure-activity relationship studies of a hit from a high throughput screening

Tobinaga, Hiroyuki, Kameyama, Takayuki, Oohara, Miho, Kobayashi, Naotake, Ohdan, Masahide, Ishizuka, Natsuki, Kume, Masaharu, Tomari, Maki, Tanaka, Yoshikazu, Takahashi, Fumiyo, Kinoshita, Haruki, Shi

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2017

Langue:

english

Fichier:

PDF, 357 KB

english, 2017

27

Discovery of orally bioavailable cyclohexanol-based NR2B-selective NMDA receptor antagonists with analgesic activity utilizing a scaffold hopping approach

Anan, Kosuke, Masui, Moriyasu, Hara, Shinichiro, Ohara, Miho, Kume, Masaharu, Yamamoto, Shoichi, Shinohara, Shunji, Tsuji, Hiroki, Shimada, Shinji, Yagi, Shigenori, Hasebe, Nobuyoshi, Kai, Hiroyuki

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2017

Langue:

english

Fichier:

PDF, 486 KB

english, 2017

28

A distinct subtype of Epstein Barr virus positive T/NK-cell lymphoproliferative disorder: Adult patients with chronic active Epstein Barr virus infection-like features

Kawamoto, Keisuke, Miyoshi, Hiroaki, Suzuki, Takaharu, Kozai, Yasuji, Kato, Koji, Miyahara, Masaharu, Yujiri, Toshiaki, Oishi, Naoki, Choi, Ilseung, Fujimaki, Katsumichi, Muta, Tsuyoshi, Kume, Masaaki

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 2.97 MB

english, 2017

29

Orally Active Cephalosporins. I. Synthesis and Structure-Activity Relationships of 7β-[2-(R)-Amino-2-phenylacetamido]-3-(1H-1, 2, 3-triazol-4-yl) alkylthiomethyl-3-cephem-4-carboxylic Acid and Related Compounds

KUME, Masaharu, KUBOTA, Tadatoshi, KIMURA, Yasuo, NAKASHIMIZU, Hiromu, MOTOKAWA, Kiyoshi

Journal:

YAKUGAKU ZASSHI

Année:

1992

Fichier:

PDF, 1.26 MB

1992

30

Quality assessment of long-term stored formalin-fixed paraffin embedded tissues for histopathological evaluation

Ono, Yuko, Sato, Hiroko, Miyazaki, Toshiko, Fujiki, Katsuya, Kume, Eisuke, Tanaka, Masaharu

Journal:

Journal of Toxicologic Pathology

Année:

2018

Langue:

english

Fichier:

PDF, 2.40 MB

english, 2018

31

Discovery of naldemedine: A potent and orally available opioid receptor antagonist for treatment of opioid-induced adverse effects

Inagaki, Masanao, Kume, Masaharu, Tamura, Yoshinori, Hara, Shinichiro, Goto, Yoshihisa, Nobuhiro, Haga, Hasegawa, Tsuyoshi, Nakamura, Takashi, Koike, Katsumi, Oonishi, Shuuichi, Kanemasa, Toshiyuki, K

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2018

Langue:

english

Fichier:

PDF, 716 KB

english, 2018

32

Discovery of NR2B-selective antagonists via scaffold hopping and pharmacokinetic profile optimization

Anan, Kosuke, Masui, Moriyasu, Tazawa, Aya, Tomida, Minoru, Haga, Yoshihiro, Kume, Masaharu, Yamamoto, Shoichi, Shinohara, Shunji, Tsuji, Hiroki, Shimada, Shinji, Yagi, Shigenori, Hasebe, Nobuyoshi, K

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2019

Fichier:

PDF, 420 KB

2019

33

Discovery of NR2B-selective antagonists via scaffold hopping and pharmacokinetic profile optimization

Anan, Kosuke, Masui, Moriyasu, Tazawa, Aya, Tomida, Minoru, Haga, Yoshihiro, Kume, Masaharu, Yamamoto, Shoichi, Shinohara, Shunji, Tsuji, Hiroki, Shimada, Shinji, Yagi, Shigenori, Hasebe, Nobuyoshi, K

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2019

Langue:

english

Fichier:

PDF, 420 KB

english, 2019